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Furthermore, oxidative stress impairs the antioxidant defense system by decreasing expression of key enzymes such as GSH, catalase, superoxide dismutase and GPX, thus accelerating ferroptosis (56,57)

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10.3389/fncel.2021.695479 259 WangF.FengJ.YangY.LiuJ.LiuM.WangZ.et al (2018a)

Expected effects include- mild stinging, transient redness, mild self-limiting peel

1.1 Pharmacokinetics govern pharmacodynamics Dietary phenolic compounds are no drugs and therefore, the term pharmaco-kinetics is strictly speaking not precise, but frequently used in the context of natural plant-derived compounds