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High copper intake can affect zinc status, and more commonly documented high zinc intake induces intestinal metallothionein and causes copper deficiency

Naiki-Ito A, Asamoto M, Hokaiwado N, Takahashi S, Yamashita H, Tsuda H, Ogawa K, Shirai T

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Instead of saying "I think the last dose was okay," you can say "I had mild nausea for two days after each of my last four injections at 7.5mg, but appetite suppression is strong and weight is trending down 1.2 pounds per week." That level of detail leads to better clinical decisions

An increased Kyn/Trp ratio reflects increased IDO1 activity, which can be induced by pro-inflammatory cytokines, including interferon- (IFN-), IL-6, and IL-1 [80]