5l (n = 5 per group) c , Weight loss curves of female Cse KO mice on No Cys diet for 7 days, followed by either 7 days on Ctrl diet or Vit-B5 (Pan) free diet followed by 7 days on a Ctrl diet or a Vit-B5 free diet supplemented with 280 mg/l of Vit-B5 (Pan) (n = 4 per group)
The SASP damages surrounding tissue, drives chronic inflammation, and converts neighboring healthy cells into senescent ones (van Deursen, 2014)
Multivitamin and dietary supplements have many uses and are popular among the general population, and demand for antiaging supplements is on the rise.15 It is estimated that more than 50% of adults in the United States take vitamin supplements, and this percentage is expected to increase in coming years.77 Vitamins and other supplements are perceived as natural and safe,77 but the evidence supporting their effectiveness is weak
doi: 10.3233/jad-132237 5 ArendtT.BrcknerM
Avoid self-administration and consult a doctor if pregnant, lactating, or managing chronic conditions