256,257 Additionally, alanyl-tRNA synthetase 2 (AARS2) has been shown to act as a mitochondrial lactyltransferase as well, catalyzing the lactylation of K336 in pyruvate dehydrogenase complex 1 (PDHA1) and K457/8 in carnitine palmitoyltransferase 2 (CPT2) under hypoxic conditions
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Inhibition of Glutathione Synthesis: Some studies suggest that NSAIDs may interfere with the production of glutathione by affecting the availability of its precursor molecules, such as cysteine
Carboxypeptidases of the SC subfamily are involved in cell signaling as a consequence of their selectivity toward small peptides
For research where selectivity isn't critical (or where ACTH-axis effects are part of the research question), the older GHRPs might still be appropriate tools