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The observed association between GLP-1s and bone health warrants further investigation into the impact of rapid weight loss on bone remodeling markers and fracture risk, particularly in older adults

doi: 10.1016/j.envint.2021.106730 122 ShankarATeppalaSSabanayagamC

JAKi interfere with the signal transducers and activators of the transcription (STAT) pathway, crucial for intracellular signaling of inflammatory mediators involved in immune function, including growth factors, interferons, and interleukins

Non-limiting examples of host cells suitable for expression of these peptides are Escherichia coli, Saccharomyces cerevisiae and mammalian BHK or CHO cell lines