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The actin-binding region itself has been linked to vascular activity: a 2003 study in the FASEB Journal reported that the site promoting actin interaction is also associated with angiogenic activity in experimental models

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140 The mechanism by which blood excess vitamin B 12 occurs in patients in the intensive care unit is not clear, but some factors that may partially explain it include: 1) the elevated plasma levels of the cobalamin-carrier proteins, the transcobalamins I and III