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Questioning whether treatment is worth continuing

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In isolated mouse islets, neutralizing GIP immune responses led to a reduction in glucose-stimulated insulin secretion, aligning with the idea of local release of an insulinotropic GIP peptide from -cells [20]

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Conversely, although off-label use of GLP-1 RA for overweight and obesity cannot be excluded, such use was likely limited in the present study given existing prescription guidelines and regulatory vigilance

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