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Los medicamentos GLP-1 aprobados por la FDA, como semaglutida (Ozempic, Wegovy) y liraglutida (Victoza, Saxenda), producen aumentos farmacolgicos sostenidos en la actividad del receptor de GLP-1, resultando en reducciones de hemoglobina A1c de 1.0-1.5% y prdida de peso de 10-15% o ms

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