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37 Necroptosis is a regulated form of necrotic cell death initiated by the binding of tumor necrosis factor (TNF)- to its receptor TNFR1, forming a multiprotein signaling complex

Notably, LY is released more rapidly than DOX, which sensitizes tumor cells to DOX by inhibiting autophagy, thereby enhancing its cytotoxicity, preventing proliferation, and promoting apoptosis in oral cancer cells (Saiyin et al

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IL-6 drives the acute-phase response and may amplify the inflammatory response that contributes to a cytokine storm

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