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10.1016/j.ctim.2019.02.014 15 AssisR

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

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Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations

However, significant challenges remain, including the synthesis of stable tripeptides with good tissue penetration, insufficient understanding of their mechanisms of action, the scarcity of studies in larger animal models and human trials, and the lack of direct head-to-head comparisons with larger peptides [75, 95]