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A pivotal RCT in 116 cannabis-dependent adolescents found that NAC (1,200 mg twice daily) more than doubled the odds of a negative urine cannabinoid test compared to placebo (OR 2.4, 95% CI 1.1-5.2) (Gray et al., Am J Psychiatry, 2012) [76]

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These paradoxical results could be observed in some other studies, such as the Keap1-Nrf2 axis in acute lung injury, in which Keap1 expression increased in some animal and in vitro experiments (Huang et al., 2020

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Single colonies were counted after two days of incubation at 30 C