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While serious, life-threatening, or fatal respiratory depression can occur at any time during the use of hydrocodone bitartrate and acetaminophen tablets, the risk is greatest during the initiation of therapy or following a dosage increase

Wilkinson L, Holst-Hansen T, Laursen PN, Rinnov AR, Batterham RL, Garvey WT

Guan, X., Hoffman, B., Dwivedi, C

If infection is the cause, fever, nausea, vomiting, chills, cramping, and constipation may occur as well

Hepatology 71(5):18511864 Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp-Arida A, Yeh M (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease