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Despite the comprehensive synthesis of pathophysiological mechanisms and therapeutic strategies in endometriosis-associated infertility, current evidence is limited by methodological biases, including predominance of observational studies and insufficient RCTs

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Gynecol Endocrinol 2019;35(3):198-206 Fruzzetti F, Perini D, Russo M, Bucci F, Gadducci A

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Through integrated transcriptomic and metabolic analyses, we found that NOTCH1 -mutated cells exhibit a distinct bioenergetic profile, characterized by upregulation of mitochondrial programs, enhanced oxidative phosphorylation, and elevated ROS production, all hallmarks of an active mitochondrial phenotype (Figs