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Single doses of SAR441255 up to 150 g were well tolerated and the most frequent treatment-emergent adverse events were gastrointestinal disorders, as is typical with these compounds
Side effects such as nausea and fatigue are common
It was initially thought that the anti-diabetic effects of DPP-4 inhibition were predominantly due to the enhanced levels of intact GLP-1 [because the insulinotropic effect of GIP is substantially impaired in subjects with T2DM (42)], but this now seems not to be the case
youre just making sure you get enough when your normal feelings of hunger arent working like they usually do
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