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Although some theorize that Tesamorelin's effects might be related to molecules like IGF-1, the study did not find a notable connection between changes in IGF-1 levels and shifts in muscle size or density

Johansen PB, et al

and similar results have been reported in humans (Burk et al., 2006)

Researchers posited that the peptide caused an increase in total pituitary RNA and GH mRNA, suggesting that proliferation of somatotroph cells had occurred, as confirmed by immunohistochemistry images . Conversely, Ipamorelin might preferentially target a distinct class of receptors believed to be growth hormone secretagogue receptor 1a (GHS-R1a), commonly called ghrelin receptors, which endogenously respond to the hormone ghrelin, according to research by Jimnez-Reina et al