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TGF1 exacerbates bloodbrain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5

1d was driven by bioisosteric replacement of the fragments bound to subpockets A-C, scaffold-hopping, de novo design, and medicinal chemistry and was facilitated by SZMAP/GamePlan 37 , vBrood 38 , and MOE software 39

Compounded peptides are not FDA approved

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however, the exact enzymes involved are poorly understood