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10.1038/cddis.2010.36 18

Central nervous system involvement is further supported by GLP-1 production in caudal brainstem neurons, key integrators of vagus nerve-mediated gut-brain signaling 53,54,55,56

Adjustments to the dosing regimen may be necessary based on individual response and tolerance

Most of the CDDO-ME subjects also exhibited fluid retention with an increase in blood pressure, heart rate, and serum brain natriuretic peptide (BNP) in addition to a decrease in blood concentrations of albumin and hemoglobin compared to the placebo subjects