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Depending on their subtype, TAMs can produce either pro-inflammatory cytokines (e.g., IL-1 and IL-6) or anti-inflammatory cytokines (e.g., IL-4 and IL-10), thereby modulating the cytokine profile and shifting the tumor microenvironment toward either tumor suppression or tumor promotion (91)

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Both reduced folate carrier and proton-coupled folate transporter are the most common ways used by folates to reach tissues

By improving liver function, it ensures the body's metabolic processes run smoothly, supporting weight management