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In the SURPASS-2 trial, patients with obesity and T2D who received tirzeapatide (5 mg weekly) achieved greater HbA1c and body weight reductions than those receiving semaglutide (1 mg weekly) during the 40 week study (64) despite comparable putative GLP-1R occupancy at these doses (47)

Sources: EMBRAZE Phase 2 press release Scholar Rock, June 2025 EMBRAZE full publication Nature Medicine, 2026 BELIEVE trial: bimagrumab + semaglutide HCPLive, May 2026 Lilly pauses bimagrumab trial BioPharma Dive, Sept

Research by Heffernan et al

Weiss FD, Calderon L, Wang YF, Georgieva R, Guo Y, Cvetesic N, et al