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Among the numerous partners that interact with NRF2 regulating its activity, two members of the CNC-bZIP protein family BTB and CNC homolog 1 (BACH1) and BTB and CNC homolog 2 (BACH2) are two negative regulators of NRF2: they compete with NRF2 for the binding to ARE sequences of target genes, thereby preventing the production of antioxidant enzymes and cellular defense against toxicity [232, 233]

N Engl J Med 2000

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REDEFINE 2, in adults with overweight or obesity and type 2 diabetes, reported a 13.7% mean reduction at 68 weeks versus 3.4% on placebo (Lingvay et al., 2025)

Tsigos C, Chrousos GP