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Moreover, THBS1 can mitigate the menstruation-driven inflammatory response by binding to cell-surface receptors (such as a4b1 integrin) of inflammatory cells, thereby restoring the overall immune homeostasis when proceeding to the next stages of the menstrual cycle [18]

Platt TL, Beckett TL, Kohler K et al (2016) Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease

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What is a suitable substitute for Synjardy XR 51000 (metformin extendedrelease 1000 mg plus empagliflozin 5 mg) in a type 2 diabetic patient with adequate renal function and no contraindications?