Polysaccharide peptide (PSP) from Coriolus versicolor improves immune functions in patients with breast cancer
Methods Study design Representatives of the companies Bristol-Myers Squibb, Novo Nordisk, Sanofi, Merck, Novartis, Boehringer Ingelheim and Takeda were contacted with the request to provide the event numbers of acute pancreatitis with the respective drug and non-incretin comparators as well as the corresponding number of patient-years of exposure (PYOs) for the approved GLP-1 receptor agonists exenatide twice daily, exenatide weekly, liraglutide and lixisenatide, as well as the DPP-4 inhibitors sitagliptin, saxagliptin, vildagliptin, alogliptin and linagliptin
Dietary nitrate is reduced to nitrite by buccal bacteria
This triple action on GIP, GLP-1, and glucagon receptors creates stronger appetite suppression and greater metabolic effects than single or dual agonist peptides