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In atherosclerosis resistant regions, the transcription factors, Kruppel-like factors (KLF) 2 and 4, are activated via MEK5/ERK5/MEF2 signaling which enhances expression of endothelial nitric oxide synthase (eNOS) (17-19)

However, outcomes are often additionally assessed for superiority when non-inferiority margins are met

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Bioavailability of tocotrienols: evidence in human studies