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Freezing irreversibly damages the medication's structure and compromises its effectiveness, even if it appears normal after thawing

Common adverse effects reported by participants who took the highest dose of retatrutide in the TRIUMPH-1 trial included nausea (42.4% of participants), diarrhoea (32.0% of participants), constipation (26.1% of participants) and vomiting (25.3% of participants)

Spironolactone has a short half-life (~1-2 days) and androgens return to baseline within weeks of stopping

Many patients use a BMI calculator before seeking treatment because it provides a quick estimate of whether they may qualify for medications such as Wegovy or Zepbound

doi: 10.4102/jir.v6i1.84