The mRNA transcripts of the GCLC subunit of glutamate cysteine ligase, which is the rate-limiting enzyme in GSH biosynthesis, as well as SLC7A11 which encodes the cystine/glutamate antiporter xCT, are previously unidentified targets for the RIDD activity of IRE1
ER Calcium Depletion and Unfolded Protein Response Chronic ethanol exposure also stimulates the release of calcium from the ER via inositol 1,4,5-trisphosphate receptors (IP 3 Rs) and ryanodine receptors (RyRs), leading to ER calcium depletion and the induction of ER stress
DNA damage uncouples the mitogenic response to IGF-I in MCF-7 malignant breast cancer cells by switching the roles of PI3 kinase and p21WAF1/Cip1
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Reza-Zaldivar EEMA, Hernndez-Sapins YK, Gutirrez-Mercado S, Sandoval-vila U, Gomez-Pinedo AL, Mrquez-Aguirre E, Vzquez-Mndez E, Padilla-Camberos AA, Canales-Aguirre