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doi:10.7759/cureus.11110 Meng Y, Chen X, Peng Z, Liu X, Sun Y, Dai S

10.3389/fnmol.2023.1166879 Front

The evidence base for Sermorelins body composition effects is older, smaller, and largely focused on lean mass and IGF-1 changes rather than targeted visceral fat reduction

Research indicates that Traditional Chinese Medicine (TCM) extracts (e.g., terpenoids, phenols, flavonoids, saponins, and alkaloids) can directly activate AMPK or regulate its upstream kinases (LKB1, CaMKK ) and downstream effectors (SIRT1, PPAR , Nrf2), thereby improving hepatic lipid accumulation, mitigating inflammatory damage, and delaying NAFLD progression

It will be interesting to see whether hypoglycemia would become more frequent or more severe if CagriSema is used in patients taking insulin or sulfonylureas