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Figure 3 As mentioned previously, GSH, a tripeptide containing glutamate, cysteine and glycine, (L--glutamyl-L-cysteinyl-glycine) is the master and most potent cellular antioxidant and the most abundant low molecular weight thiol that plays a crucial role in antioxidant defense against cellular ROS/reactive nitrogen species (RNS)-mediated oxidative damage and in the regulation of numerous metabolic pathways essential for maintaining whole body homeostasis

First, addition of Cu(II), but not other metal ions [e.g., Zn(II), Ni(II), and Al(III)] and Cd(II), to protein samples decreases the thermal stability of ubiquitin ( in vitro and in vivo (Table 1)

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Biopolymers 32 , 523535 (1992)

By doing so, individuals can actively influence their aging process, not only extending their lifespan but also preserving health, cognitive function, and physical ability throughout their later years.