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These findings provide compelling evidence that the gut microbiota can drive systemic immune modulation, offering novel insights into hostmicrobiota crosstalk and potential therapeutic interventions
For example, non-steroidal anti-inflammatory drugs often prescribed for pain management have been associated with gastrointestinal disturbances, raising concerns about their long-term use in ME/CFS patients who already report high levels of gut-related issues [185, 186]
Acknowledgements The authors would like to thank the coordinator of the THALIS project Prof
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Additionally, compared to the tumors of mice without drug treatment and those treated with Ru(II)-OH (64.4%) and NP2 (73.6%), the tumors of mice treated with NP4 (81.2%) exhibited a higher proportion of mature DCs (CD80 + CD86 + ) (Supplementary Fig
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