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A net influx of molecules into the CNS would increase osmolarity and allow water from the vasculature to enter the brain, thereby leading to an increase in intracranial pressure

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Patience during plateaus prevents counterproductive behaviors like excessive restriction or abandoning the protocol

for instance, case reports have demonstrated survival after a 25 g overdose [42] , and current guidelines in the United States and Canada indicate a high-risk ingestion to be ingestion of at least 30 g of APAP [43]