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Cardiovascular Diabetology

The article explains that spironolactone blocks aldosterone, causing the body to hold onto potassium while shedding sodium and water, while semaglutide can promote modest sodium loss and shift fluid balance as weight comes down

Key Benefits: Dual Mechanism of Action: Simultaneously stimulates GIP and GLP-1 receptors for comprehensive metabolic benefits

This reduces the risk of hypoglycemia when used alone, though the risk increases when combined with insulin or sulfonylureas

In clinical trials, patients lost an average of 5% of their body weight (~10-12 lbs.) after 20 weeks and close to 15% (~30 lbs.) after 1 year on the highest 2.4 mg dose