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ADX71743 (12.5 and 100 mg/kg, subcutaneous injection, single dose) demonstrates bioavailability in C57Bl6/J mice, penetrates the blood-brain barrier (CSF/plasma concentration ratio was 5.3% at Cmax), shows linear increases in plasma exposure with increasing dose, and is cleared rapidly (half-life approximately 0.5 hours)
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Therefore, more researches in the future are also needed to establish models in suitable animals, such as orangutans, which have similar physiological structures and physiological mechanisms as humans
