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Studies have demonstrated that GPS exhibits significant anti-inflammatory effects by modulating immune responses and regulating cytokine production (Niu et al., 2016

For example, while low-dose polyphenols stimulate endogenous antioxidant defenses, high concentrations, such as those found in concentrated supplements, can act as potent pro-oxidants, leading to increased oxidative stress and cellular damage 51

Whether that premium is justified depends on individual factors

However, because of the shortage in low-dose versions of the drug, she may be more likely to experience nausea as a side effect