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If body composition or glucose regulation is off, GLP-1 therapy does more for healthspan than any peptide, with phase 3 evidence behind it (14.9% weight loss in STEP 1, Wilding 2021 NEJM

If tests show deficiency, replacement is justified and often rapidly helpful

GSH concentration is instead measured by either of two methods: by analysis of GS-NEM conjugates by HPLC in the same sample that is used to measure GSSG or, alternatively, by analysis of GSH by spectrophotometry (GSH recycling method) on one additional sample aliquot that has not been derivatized with NEM

However, its primary role is as an antioxidant, crucial for numerous bodily processes, including detoxification, skin health, and immune support

Con: kidney biopsy: an irreplaceable tool for patient management in nephrology