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Additionally, UPLC-MS/MS was applied to determine the drug concentration of etomidate, remifentanil, and rocuronium bromide for general anesthesia in fetuses as well as the placental transport rate between full-term and pre-term delivery, twins, and singletons [80]

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Five DEGs were involved in the biosynthesis of 4 proteins required in the pathway of one-carbon pool by folate, among which the 5-formyltetrahydrofolate cyclo-ligase (MTHFS) has a scavenger role as the only enzyme that converts 5-formyl-THF to 5,10-methenyl-THF [46] and showed a value of log2FC 2.69 at 3 DPI vs CK (Additional file 1: Dataset S1)

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Diacerein has been previously shown to have protective anti-apoptotic and anti-inflammatory properties via NLRP3/caspase-1/IL-1 modulation (Fouad et al