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Limit or avoid caffeine (coffee, tea, energy drinks) on the day of treatment, if possible, as it may cause dehydration

These observations strongly suggest that Ccrk acts as a major upstream regulator of Mak and Ick in retinal photoreceptor cells, which is supported by previous reports showing that Ccrk directly phosphorylates Ick and Mak at Thr-157 in vitro (68, 71)

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