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Cagrilintide functions primarily through amylin receptor complexes, which are heterodimers formed by the calcitonin receptor and receptor activity modifying proteins

Effects on cognition and global function were evaluated with the Alzheimers Disease Assessment Scale Cognitive Subscale (ADAS-Cog) and the Clinician Interview-Based Impression of Change with Caregiver Input scale (CIBIC+) at 4, 12, and 24 weeks after the start of injections

Transcriptomic analysis of iSPNs at the pre-symptomatic stage showed de-regulation of metabolic pathways, including upregulation of Gsto2 , encoding glutathione S-transferase omega-2 (GSTO2)