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While mutagenesis studies clearly reveal that these residues within TM2 and ECL2 are important for both GLP-1 and oxyntomodulin function, alanine mutations in these regions generally had a larger impact on GLP-1 (Figures 4-5, Supplemental Figures 9-10)

Medication timing and dosing considerations may help minimize taste-related side effects

[DOI] [PubMed] [Google Scholar] 30.Tedeschi M, De Cesare A, Oriana S, Perego P, Silva A, Venturino P, Zunino F

From Superoxide to Oxidative and Nitrosative Injury Terminology matters: peroxynitrite is ONOO