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Based on simulations, the average concentration at day 10 was 66% of exposure at steady state, and the accumulation ratio was estimated to be 12.6 from day 1 to steady state (computed via simulations including inter-individual variability and inter-occasion variability)

For a 2mg dose using the Ozempic 8mg/3mL pen (concentration 2.67mg/mL), this equals approximately 75 units when calculated using standard U-100 insulin syringe measurements