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In the Phase 2 trial, retatrutide 12 mg weekly produced mean weight loss of 24.2% at 48 weeks, with the highest-dose group achieving 28.7% at the same timepoint in the TRIUMPH-4 Phase 3 trial

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Despite taking maximal doses of metformin, her glycemic control was suboptimal, with a hemoglobin A1C (HbA1c) of 9.2 percent

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Protein matters while taking Semaglutide because weight loss can include both fat loss and lean mass loss if nutrition and strength activity are not planned carefully