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Materials and methods Search strategy The PubMed, EMBASE and Web of Science databases were searched in March 2025 for peer-reviewed English-language randomised controlled trials (RCTs)
In the Tang Dynasty (618-901 AD ) another surgeon, Fang Kan, was designated as the doctor of lip repair from which he obtained considerable repute. The story of the first well-described cleft lip repair, also retold by Boo-Chai, 9 dates back to 390 AD and comes from the text of the Chin Annals , an official history of the Chin Dynasty commissioned by Emperor Tang Tai-Tsung (627-650 AD )
It assists in the control of the melanin production and minimisation of the excess pigmentation
50 , 113128 (2007) Guzman-Perez, A
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