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In addition, the granule enzyme B released by CD8+ T cells inactivates GPX4 by cleaving its C-terminal domain and degrades ferroptosis suppressor protein 1 (FSP1), resulting in a collapse of the tumor cells antioxidant defense system (222)

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LRE mechanistically elevated antioxidant enzymes such as GPX-4, Prdx-5, HO-1, and SOD-2, which are essential for alleviating oxidative damage