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The level of VEGF-A significantly increased from 75.6 to 138.6 pg/mL in high glucose (HG)-stimulated human retinal endothelial cells (HRECs) but decreased to 102.1 pg/mL and 92.5 pg/mL with 50 nM and 100 nM liraglutide, respectively

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the FDA approved the first such drug, exenatide, in 2005

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