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Male BALB/c-nu nude mice aged 4 weeks and weighing 18 ~ 22 g were purchased from the Experimental Animal Centre of Southern Medical University (Guangzhou, China) and housed in a specific pathogen-free air-conditioned room (25 2 and 65% 5% humidity) with a 12-h light/dark cycle
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However, this increase in metabolic activity is also associated with elevated ROS, which are known modulators of the functions of immune cells 32,41,43,44,103
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