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In fact, continuous GH elevation from CJC1295 with DAC can lead to desensitization of GH receptors over time

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Approach Extended On-cycle 5-6 weeks Off-cycle 6 weeks minimum Best for Used only after prior cycles confirmed glucose tolerance

Gonadotropin releasing hormone agonists, such as goserelin, are employed to induce a hypoestrogenic state by initially stimulating and then downregulating pituitary hormone secretion, whereas gonadotropin releasing hormone antagonists, directly block receptor binding for a more rapid onset of action (5)