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Inhibition of the target gene expression can occur through various mechanisms such as RNA interference, once the sense-antisense mRNA duplex has formed, transcriptional interference, in which the NAT can act as a physical barrier for RNA polymerase activity, or epigenetic methylation of the sense gene DNA, thus inhibiting the transcription of the sense mRNA transcript [55, 56]

Biochim Biophys Acta 1117: 120125

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Similar content being viewed by others Introduction Some of the most frequently injured sites of the human body involve soft tissues including skeletal muscles, tendons and ligaments

View at Publisher | View at Google Scholar Wegovy (semaglutide) injection