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In addition, wild-type rodent GRP transplantation led to the reduction of microgliosis, implicating a positive anti-inflammatory effect of wild-type astrocytes [37]

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The study by Ferguson et al [45] is also the only study that has examined the effect of reninangiotensinaldosterone-system (RAAS) inhibitors on renal ADC

As sDPP4 is an adipokine upregulated in obesity and T2DM that triggers IR and metabolic complications ( However, whether these beneficial effects observed in pre-clinical settings are due to increased levels of different DPP4 substrates or inhibition of direct effects of DPP4 remains unclear and will be assessed in more detail in the following section