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The main distinction is that VELO Nicotine Pouches are tobacco-free

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[43] Clonidine may reduce withdrawal symptoms and "approximately doubles abstinence rates when compared to a placebo," but its side effects include dry mouth and sedation, and abruptly stopping the drug can cause high blood pressure and other side effects

BMJ Open 6(10):e012693 Reid JL, Mutti-Packer S, Gupta PC et al (2017) Influence of health warnings on beliefs about the health effects of cigarette smoking, in the context of an experimental study in four Asian countries