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Yes, and in many cases, the combination is more effective than either approach alone

Because gastrointestinal absorption of protein-bound B can be impaired in patients on proton-pump inhibitors or metformin, parenteral or high-dose oral methylcobalamin offers a bioavailable alternative

7.63%), 3 years (29.62% vs

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The internalizing mechanism of CPPs is largely dependent on the properties of CPPs, cell types (membrane compositions and cellular machineries for uptake), transported cargos (concentration, structure, and linking methods), and the experimental conditions (pH and temperature) (Xie et al., 2020)