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New populations emerge to fill the altered ecological niche

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In a randomized controlled trial, the GLP-1R agonist exenatide showed reduced alcohol intake in a subgroup of people with both obesity and alcohol use disorder

Chronic administration study Finally, to determine whether exendin-phe1 beta cell effects persist with chronic administration, we administered agonists continuously to HFHS-fed mice for 2 weeks via subcutaneous minipumps, using a relatively low dose of agonist (0.24 nmol kg 1 day 1 ) to reduce the weight-dependent effects