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Using C2C12 mouse myoblasts, the study confirmed that the MGF E-domain peptide increases myoblast proliferation while inhibiting terminal differentiation and critically, that this effect was maintained in the presence of a neutralising anti-IGF-1R antibody directly establishing that MGF E-peptide signals via an IGF-1R-independent mechanism

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Blood 116 , 40254033 (2010)

J Genet Genomics Yi Chuan Xue Bao

People with severe deficiencies may require a few injections to start feeling the benefits and will be overseen by a medical professional to ensure accurate dosage to optimise results